Using quercetin to prevent squamous cell carcinoma in children with Fanconi anemia

Who could benefit from this research

What this research studies

This research investigates the use of quercetin, a natural compound, to prevent the development of squamous cell carcinoma (SCC) in children with Fanconi anemia (FA). Current treatments for SCC, such as radiation and chemotherapy, can cause severe side effects, so this study aims to find a safer alternative. The researchers hypothesize that quercetin can reduce harmful reactive-oxygen species (ROS) in patients, potentially lowering the risk of SCC. Preliminary data suggest that quercetin may reverse DNA damage in tumor cells associated with FA, making it a promising candidate for treatment.

Why it matters

Where this research is happening

• Cincinnati Childrens Hosp Med Ctr
  Cincinnati, United States Active

Researchers

• Principal investigator: Mehta, Parinda a. — Cincinnati Childrens Hosp Med Ctr
• Study coordinator: Mehta, Parinda a.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.