Using quercetin to prevent squamous cell carcinoma in children with Fanconi anemia
IND: 113343 Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients with Fanconi Anemia
This study is looking at whether quercetin, a natural substance, can help prevent squamous cell carcinoma in children with Fanconi anemia by reducing harmful effects in their bodies, offering a safer option than current treatments like radiation and chemotherapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10652481 on NIH RePORTER |
What this research studies
This research investigates the use of quercetin, a natural compound, to prevent the development of squamous cell carcinoma (SCC) in children with Fanconi anemia (FA). Current treatments for SCC, such as radiation and chemotherapy, can cause severe side effects, so this study aims to find a safer alternative. The researchers hypothesize that quercetin can reduce harmful reactive-oxygen species (ROS) in patients, potentially lowering the risk of SCC. Preliminary data suggest that quercetin may reverse DNA damage in tumor cells associated with FA, making it a promising candidate for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Fanconi anemia who are at risk for squamous cell carcinoma.
Not a fit: Patients without Fanconi anemia or those who do not have a risk of developing squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer treatment option for children with Fanconi anemia at risk of developing squamous cell carcinoma.
How similar studies have performed: Previous studies have shown that quercetin can prevent or modulate SCC formation in non-FA settings, indicating potential success for this approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Mehta, Parinda a. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Mehta, Parinda a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.