Using pulsed ultrasound to reduce inflammation and prevent acute kidney injury
Proof of concept and feasibility in humans for pulsed ultrasound treatment to reduce inflammation and risk of AKI
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10980616
This study is looking at whether pulsed ultrasound can help reduce inflammation and lower the risk of kidney problems in patients, and if you join, you might receive this gentle treatment while we keep an eye on how your kidneys are doing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10980616 on ClinicalTrials.gov |
What this research studies
This research investigates the use of pulsed ultrasound as a non-invasive treatment to reduce inflammation and the risk of acute kidney injury (AKI) in patients. The approach is based on previous findings that ultrasound can activate the body's inflammatory reflex, potentially leading to protective effects on the kidneys. By focusing on the mechanisms involved, the study aims to establish the feasibility of this treatment in humans, addressing a significant gap in current AKI management. Patients participating in this research may receive ultrasound treatments while being monitored for changes in kidney function and inflammation levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are at risk for or have experienced acute kidney injury.
Not a fit: Patients with chronic kidney disease or those who do not meet the age and health criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel, non-invasive treatment option for patients at risk of acute kidney injury.
How similar studies have performed: While the use of ultrasound in this context is novel, preliminary animal studies have shown promising results in reducing inflammation and preventing kidney injury.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OKUSA, MARK DOUGLAS — UNIVERSITY OF VIRGINIA
- Study coordinator: OKUSA, MARK DOUGLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.