Using psilocybin to improve mood and pain in patients with chronic back pain and depression
Psilocybin and Affective Function in Chronic Lower Back Pain and Depression
This study is looking at how psilocybin, a natural substance found in some mushrooms, might help people with chronic low back pain and depression feel better by improving their mood and reducing pain, and it's designed for those who haven't found relief with other treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11077883 on NIH RePORTER |
What this research studies
This research investigates the effects of psilocybin, a psychedelic compound, on patients suffering from chronic low back pain and depression. The study aims to understand how psilocybin can enhance emotional well-being and reduce pain perception by targeting specific brain mechanisms. Participants will receive psilocybin in a controlled setting, and their responses will be monitored to assess improvements in mood and pain management. This approach seeks to provide a new treatment avenue for individuals who have limited options for managing their symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic low back pain along with depressive symptoms.
Not a fit: Patients who do not have chronic low back pain or depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a novel, effective treatment for patients struggling with both chronic pain and depression.
How similar studies have performed: Previous research has shown promising results using psilocybin for improving mood and pain management in other patient populations, indicating potential for success in this study.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Yaden, David Bryce — Johns Hopkins University
- Study coordinator: Yaden, David Bryce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.