Using propofol to improve sleep and reduce depression in older adults
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Trial
This study is looking at how a common anesthesia drug called propofol might help older adults with treatment-resistant depression get better sleep and improve their thinking skills, by giving them personalized doses and tracking how it affects their sleep and brain activity.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11013406 on NIH RePORTER |
What this research studies
This research investigates how propofol, a medication commonly used for anesthesia, can be repurposed to enhance slow wave sleep in older adults suffering from treatment-resistant depression (TRD). The study aims to understand the connection between sleep disturbances and cognitive issues in this population by administering personalized propofol infusions and monitoring their effects on brain activity and sleep patterns. Participants will undergo two phases of clinical trials, where the first phase will determine the optimal dose of propofol to induce slow waves, and the second phase will assess its impact on cognitive outcomes. By focusing on the relationship between sleep and depression, this research seeks to develop innovative treatment strategies for older adults facing these challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing treatment-resistant depression and associated sleep disturbances.
Not a fit: Patients who do not have treatment-resistant depression or significant sleep issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for older adults with treatment-resistant depression, potentially improving their sleep quality and cognitive function.
How similar studies have performed: While the use of propofol for sleep induction is established, this specific approach targeting slow wave sleep in the context of depression in older adults is novel and has not been extensively tested.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Palanca, Ben Julian — Washington University
- Study coordinator: Palanca, Ben Julian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.