Using probiotics to improve gut health and reduce cognitive decline in Alzheimer's disease
Microbial therapy improves gut permeability to reduce cognitive decline and Alzheimer’s disease
This study is looking at how a special heat-killed probiotic called Lactobacillus paracasei D3-5 might improve gut health and help protect against memory problems as we age, especially for those concerned about Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10892340 on NIH RePORTER |
What this research studies
This research investigates how a specific heat-killed probiotic, Lactobacillus paracasei D3-5, can enhance gut health by restoring mucin production, which may help reduce gut permeability. The study aims to understand the connection between gut health and cognitive decline associated with aging and Alzheimer's disease. By examining the effects of this probiotic on inflammation and cognitive function in older adults, the research seeks to provide insights into potential therapeutic approaches for Alzheimer's disease. Patients may be monitored for changes in cognitive abilities and gut health throughout the study.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease.
Not a fit: Patients with non-age-related cognitive impairments or those not experiencing any cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new probiotic treatments that improve gut health and slow cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results using probiotics to improve gut health and cognitive function, suggesting potential success for this approach.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yadav, Hariom — University of South Florida
- Study coordinator: Yadav, Hariom
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.