Using pressure to enhance imaging during surgery.
Official title: Pressure-Enhanced Sensing Surgery (PRESS) as a tool for surgical guidance.
Funded at Doseoptics, LLC · NIH-10922124 · Data updated 2026-11-12
This study is testing a new imaging method that helps surgeons see and understand tissue better during operations, especially for pancreatic tumors, so they can make more informed decisions while performing surgery.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doseoptics, LLC NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | June 1, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $295,747 |
| NIH project number | 1R43CA291522-01 |
| Project ID | NIH-10922124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing surgery for pancreatic tumors or other solid cancers where precise imaging is critical.
✕Less likely to help
Patients with non-cancerous conditions or those not requiring surgical intervention may not benefit from this research.
What this research studies
This research investigates a novel imaging technique called Pressure-Enhanced Sensing Surgery (PRESS) that utilizes a contrast agent to improve the visualization of tissue during surgical procedures. By administering a prodrug that fluoresces in low-oxygen environments, surgeons can obtain real-time images of tissue function and vascular dynamics while palpating the area. This approach aims to enhance the precision of oncologic surgeries, particularly for pancreatic tumors, by providing immediate feedback on tissue characteristics. The study will explore the effectiveness of this imaging method in guiding surgical decisions.
Why it matters
Potential benefit: If successful, this research could significantly improve surgical outcomes by allowing for more precise tumor resections and better preservation of healthy tissue.
How similar studies have gone: While the concept of using fluorescence in surgery is established, the specific application of PRESS as a dynamic imaging tool is novel and has not been widely tested.
Where this research is happening
-
Doseoptics, LLC
Lebanon, United States Active
Researchers
- Principal investigator: Ware, William — Doseoptics, LLC
- Study coordinator: Ware, William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.