Using precision medicine to improve glucocorticoid treatment in sepsis
Precision Medicine Approach to Glucocortisteroids in Sepsis
This study is looking at how to make glucocorticoid treatments for sepsis more effective by understanding which patients will benefit the most, using data from past trials and health records to create personalized treatment plans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10912667 on NIH RePORTER |
What this research studies
This research investigates how to tailor glucocorticoid treatments for patients with sepsis by analyzing various patient characteristics and responses to treatment. By creating a 'knowledge network' that combines data from multiple clinical trials and electronic health records, the study aims to identify which patients are most likely to benefit from glucocorticoids. The approach utilizes advanced machine learning techniques to better understand the effects of treatment based on individual patient profiles. This could lead to more effective and personalized treatment strategies for sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who may require glucocorticoid treatment.
Not a fit: Patients with sepsis who are not candidates for glucocorticoid therapy or those with contraindications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment outcomes for patients with sepsis by providing personalized glucocorticoid therapies.
How similar studies have performed: Previous research has shown mixed results with glucocorticoid treatments in sepsis, indicating that this precision medicine approach could provide new insights and potentially improve outcomes.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Yende, Sachin — University of Pittsburgh at Pittsburgh
- Study coordinator: Yende, Sachin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.