Using prebiotics to improve gut health and outcomes after stem cell transplants
Prebiotics to Optimize the Microbiota and Improve Outcomes of AllogeneicHematopoietic Stem Cell Transplantation
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11178858
This study is looking at how a special type of fiber called galacto-oligosaccharides (GOS) can help improve gut health for patients getting a stem cell transplant, with the hope of reducing complications like graft-versus-host disease and making recovery easier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11178858 on ClinicalTrials.gov |
What this research studies
This research investigates the use of prebiotics, specifically galacto-oligosaccharides (GOS), to enhance gut microbiota in patients undergoing hematopoietic stem cell transplantation (HCT). The study aims to evaluate the safety and effectiveness of GOS in reducing complications such as graft-versus-host disease (GVHD), which occurs when the donor's immune cells attack the recipient's tissues. By improving the gut bacteria and increasing beneficial metabolites like butyrate, the research seeks to improve patient outcomes and reduce treatment-related mortality. Patients will be enrolled in a phased trial to assess the maximum tolerated dose and overall impact of GOS on their health.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled to undergo allogeneic hematopoietic stem cell transplantation.
Not a fit: Patients who are not undergoing stem cell transplants or those with contraindications to prebiotic treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing stem cell transplants.
How similar studies have performed: Previous research has shown promising results with prebiotics in improving gut health, but this specific application in HCT is novel.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUNG, ANTHONY — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: SUNG, ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.