Using plant virus-like particles to deliver cancer treatment
Dual-pronged nano-drug delivery using plant virus-like particles
This study is exploring a new way to help people with triple negative breast cancer by using a plant virus to boost the immune system's ability to fight the tumor, and it also includes testing the treatment in dogs with breast cancer to see how well it works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10903775 on NIH RePORTER |
What this research studies
This research focuses on treating triple negative breast cancer (TNBC) by utilizing plant virus nanoparticles to enhance the immune response against tumors. The approach involves injecting cowpea mosaic virus (CPMV) directly into the tumor, which activates the body's immune cells to fight cancer more effectively. The research aims to personalize treatment by targeting unique markers found in each patient's tumor, potentially leading to better outcomes. Additionally, the study includes trials in companion dogs with breast cancer to further understand the treatment's efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple negative breast cancer who are seeking innovative treatment options.
Not a fit: Patients with other types of breast cancer or those who do not have access to the treatment location may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized immunotherapy options for patients with triple negative breast cancer.
How similar studies have performed: Previous studies have shown promising results using similar nanoparticle approaches in cancer treatment, indicating potential for success in this novel application.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Steinmetz, Nicole Franziska — University of California, San Diego
- Study coordinator: Steinmetz, Nicole Franziska
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.