Using PhytoSERM to help manage menopausal hot flashes and support brain health.
Official title: PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health
Funded at Neutherapeutics, LLC · NIH-10707107 · Data updated 2026-11-12
This study is looking at how a new treatment called PhytoSERM can help relieve menopausal symptoms like hot flashes and support brain health in women going through menopause, offering a safer option than traditional hormone therapy.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neutherapeutics, LLC NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,199,342 |
| NIH project number | 5R44AG078102-02 |
| Project ID | NIH-10707107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are symptomatic peri- and post-menopausal women experiencing hot flashes and at risk for Alzheimer's disease.
✕Less likely to help
Patients who are not experiencing menopausal symptoms or who are not female may not benefit from this research.
What this research studies
This research investigates the effects of PhytoSERM, a selective estrogen receptor beta modulator, on menopausal symptoms and brain health in women. The study aims to provide an alternative to traditional hormone therapy, which many women avoid due to concerns about breast cancer. By targeting estrogen action specifically in the brain while minimizing effects in breast tissue, PhytoSERM could help alleviate hot flashes and potentially reduce the risk of Alzheimer's disease. The research involves a Phase 2 clinical trial with a randomized, placebo-controlled design to assess the efficacy and safety of PhytoSERM in peri- and post-menopausal women.
Why it matters
Potential benefit: If successful, this research could provide a safer treatment option for menopausal symptoms while also supporting cognitive health in women.
How similar studies have gone: Previous studies have shown promising results with similar approaches, indicating potential for success in this area.
Where this research is happening
-
Neutherapeutics, LLC
Tucson, United States Active
Researchers
- Principal investigator: Rinehart, John — Neutherapeutics, LLC
- Study coordinator: Rinehart, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.