Using PET imaging to evaluate aortic aneurysms in patients
PET Imaging of MMP Activation in AAA: First in-Human Evaluation
This study is looking at new imaging techniques to see how certain proteins behave in patients with abdominal aortic aneurysms, helping doctors better understand the condition and make more informed treatment decisions, especially for those who might not need surgery right away.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10824316 on NIH RePORTER |
What this research studies
This research investigates the use of advanced PET imaging techniques to assess the activation of matrix metalloproteinases (MMP) in patients with abdominal aortic aneurysms (AAA). The study aims to improve the understanding of aneurysm behavior, particularly in cases that do not meet traditional surgical criteria. By developing novel imaging tracers, the research seeks to provide better risk stratification and potentially guide treatment decisions for patients with AAA. Participants will undergo imaging procedures to evaluate the effectiveness of these new tracers in detecting vascular changes associated with aneurysms.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with abdominal aortic aneurysms, particularly those with smaller aneurysms that may not typically qualify for surgical repair.
Not a fit: Patients without abdominal aortic aneurysms or those who are not within the older adult age group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying patients at risk of aneurysm rupture, potentially saving lives through earlier intervention.
How similar studies have performed: Previous research has shown promise in using molecular imaging techniques for vascular conditions, but this specific approach with PET imaging for AAA is novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sadeghi, Mehran M — Yale University
- Study coordinator: Sadeghi, Mehran M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.