Using PET imaging to detect inflammation changes after brain injuries
Official title: Feasibility of Using PET Imaging for Detection of Treatment-Induced Changes in Chronic Neuroinflammation Following TBI
Funded at Veterans Health Administration · NIH-10897840 · Data updated 2026-11-12
This study is looking at how a special brain scan can help us see inflammation in the brain caused by traumatic injuries, like falls or sports accidents, and it will also test if a medication called methylphenidate can help improve brain function for people dealing with these injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I21RX004644-02 |
| Project ID | NIH-10897840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic brain injuries and are suffering from chronic neuroinflammation-related symptoms.
✕Less likely to help
Patients who have not experienced a traumatic brain injury or do not exhibit symptoms of chronic neuroinflammation may not benefit from this research.
What this research studies
This research investigates how PET imaging can be used to monitor chronic neuroinflammation resulting from traumatic brain injuries (TBI). It aims to develop a platform that can detect these changes and evaluate the effectiveness of a medication called methylphenidate in enhancing brain function. The study uses a rat model that simulates common causes of TBIs, such as falls and sports injuries, to understand the long-term effects of these injuries on brain health. By focusing on the brain's immune response, the research seeks to provide insights into improving treatment for individuals affected by TBIs.
Why it matters
Potential benefit: If successful, this research could lead to better detection and treatment strategies for chronic neuroinflammation in patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown promise in using imaging techniques to study brain injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Veterans Health Administration
Gainesville, United States Active
Researchers
- Principal investigator: Bose, Prodip K. — Veterans Health Administration
- Study coordinator: Bose, Prodip K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.