Using patients' own skin cells to improve prosthetic use for amputees
Injection of autologous volar fibroblasts to the stump site to allow pressure adaptation and enhanced prosthetic use in amputees
This study is looking at a new way to help people with amputations feel more comfortable with their prosthetics by using their own skin cells to improve the skin on their stump, making it better at handling pressure and reducing the risk of sores.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11046567 on NIH RePORTER |
What this research studies
This research aims to enhance the quality of life for amputees by injecting their own skin cells, specifically fibroblasts, into the stump site where the prosthetic attaches. The process involves taking a small sample of skin from the palm or sole, purifying and expanding these cells in the lab, and then injecting them into the stump to improve its ability to adapt to pressure. By studying how these injected cells interact with the native cells in the stump, the research seeks to develop a new therapy that not only aids in prosthetic use but also helps prevent pressure ulcers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone limb amputation and are seeking to enhance their prosthetic experience.
Not a fit: Patients who have not undergone amputation or those with severe skin conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the comfort and functionality of prosthetics for amputees.
How similar studies have performed: Previous research in cellular therapies has shown promise in regenerative medicine, suggesting potential success for this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Garza, Luis Andres — Johns Hopkins University
- Study coordinator: Garza, Luis Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.