Using patient-specific cells to understand and treat pulmonary fibrosis
Patient-specific iPSCs to model and treat the inception of pulmonary fibrosis
['FUNDING_P01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-11046624
This study is looking at idiopathic pulmonary fibrosis (IPF) to understand how certain lung cells behave poorly and how things like cigarette smoke might make it worse, with the hope of finding new treatments to help people with this serious lung disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11046624 on ClinicalTrials.gov |
What this research studies
This research focuses on idiopathic pulmonary fibrosis (IPF), a severe lung disease that leads to progressive scarring and can be fatal within a few years. By utilizing patient-specific induced pluripotent stem cells (iPSCs), the study aims to model the disease and investigate the role of dysfunctional alveolar epithelial cells in its progression. The researchers will explore how environmental factors, like cigarette smoke, contribute to cell dysfunction and whether these effects can be reversed. This approach seeks to provide insights that could lead to new therapies for IPF.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with idiopathic pulmonary fibrosis or those at risk due to environmental exposures.
Not a fit: Patients with other forms of lung disease unrelated to pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients with pulmonary fibrosis.
How similar studies have performed: Previous research using patient-specific cells has shown promise in understanding and treating various diseases, suggesting potential success for this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALYSANDRATOS, KONSTANTINOS — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: ALYSANDRATOS, KONSTANTINOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.