Using patient-derived stem cells to create dopamine neurons for treating Parkinson's disease
Parkinsons Disease Scalable iPSC Autologous Cell Therapy
This study is testing a new treatment for Parkinson's disease that uses your own cells to create brain cells that produce dopamine, with the hope of helping to improve your symptoms and make existing treatments work better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-10763359 on NIH RePORTER |
What this research studies
This research focuses on developing a new treatment for Parkinson's disease by using induced pluripotent stem cells (iPSCs) derived from patients' own cells to create dopamine-producing neurons. The approach aims to replace damaged neurons in the brain, which can help alleviate both motor symptoms and complications from existing treatments. The project includes a clinical trial to test the safety and effectiveness of this autologous cell therapy in patients with Parkinson's disease. By utilizing patients' own cells, the therapy aims to minimize the risk of rejection and improve long-term outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing motor symptoms and are interested in innovative treatment options.
Not a fit: Patients who do not have Parkinson's disease or those who are not suitable candidates for cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking treatment option that restores dopamine function in Parkinson's disease patients, potentially improving their quality of life.
How similar studies have performed: Previous research with fetal cell transplantation has shown promising results, indicating that similar approaches using iPSCs could also be effective, although this specific method is novel.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Hallett, Penelope Jane — Mclean Hospital
- Study coordinator: Hallett, Penelope Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.