Using parathyroid hormone to prevent post-traumatic arthritis
Official title: Modulating PTOA development with parathyroid hormone
Funded at Cornell University · NIH-10930058 · Data updated 2026-11-12
This study is looking at whether a treatment with parathyroid hormone can help protect joints from developing arthritis after an injury, using a mouse model to see how it affects joint health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $389,948 |
| NIH project number | 5R01AR081943-02 |
| Project ID | NIH-10930058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced joint injuries, such as ligament tears or cartilage damage, and are at risk of developing post-traumatic osteoarthritis.
✕Less likely to help
Patients who have not experienced joint injuries or who have advanced osteoarthritis may not benefit from this research.
What this research studies
This research investigates how intermittent treatment with parathyroid hormone (iPTH) can help prevent the development of post-traumatic osteoarthritis (PTOA) following joint injuries. The study uses a non-invasive mouse model to simulate PTOA and examines the effects of iPTH on joint health after traumatic loading. By targeting bone remodeling processes, the research aims to inhibit the progression of joint damage and improve outcomes for individuals at risk of developing PTOA after injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that prevent or slow the progression of post-traumatic arthritis in patients with joint injuries.
How similar studies have gone: Previous research has shown promising results with similar approaches targeting bone remodeling in osteoarthritis models, suggesting potential for success in this study.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Van Der Meulen, Marjolein C — Cornell University
- Study coordinator: Van Der Meulen, Marjolein C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.