Using panobinostat to treat sickle cell disease in adults
Official title: Phase I study of panobinostat in adults with sickle cell disease: novel approach to recruitment and retention
Funded at Augusta University · NIH-11034073 · Data updated 2026-11-12
This study is looking at how well a new treatment called panobinostat works for adults with sickle cell disease, aiming to help reduce pain and other issues while making sure participants feel supported throughout the process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $675,642 |
| NIH project number | 5R33HL162681-03 |
| Project ID | NIH-11034073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with sickle cell disease who are seeking alternative treatment options.
✕Less likely to help
Patients who do not have sickle cell disease or those who are not adults may not benefit from this research.
What this research studies
This research investigates the use of panobinostat, a novel treatment, for adults suffering from sickle cell disease (SCD). The study aims to improve patient recruitment and retention while assessing the drug's effectiveness in reducing painful episodes and other complications associated with SCD. Participants will be monitored closely for their response to the treatment and any side effects, contributing to a better understanding of how to manage this chronic condition. The research seeks to address the limitations of existing therapies and provide new options for patients.
Why it matters
Potential benefit: If successful, this research could offer a new treatment option that alleviates pain and improves the quality of life for adults with sickle cell disease.
How similar studies have gone: While there have been successful studies using other treatments for sickle cell disease, the use of panobinostat represents a novel approach that has not been extensively tested in this context.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Kutlar, Abdullah — Augusta University
- Study coordinator: Kutlar, Abdullah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.