Using Paneth cell characteristics to predict outcomes in ulcerative colitis
Paneth cell phenotype as a predictive biomarker for ulcerative colitis
This study is looking at how certain cells in the intestine can help doctors predict how well patients with ulcerative colitis will do after surgery, with the goal of creating better, more tailored treatment plans for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10682400 on NIH RePORTER |
What this research studies
This research investigates how the characteristics of Paneth cells, which are specialized cells in the intestine, can be used to predict the outcomes for patients with ulcerative colitis (UC). The study aims to determine if the appearance of these cells at the time of surgery can forecast complications after procedures like total colectomy and ileal pouch anal anastomosis. By employing advanced techniques, including deep learning, the researchers hope to improve the accuracy and consistency of their analyses. This could lead to more personalized treatment strategies for patients suffering from UC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ulcerative colitis who are scheduled for surgical procedures such as total colectomy.
Not a fit: Patients with ulcerative colitis who are not undergoing surgery or those with other unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a reliable biomarker to help tailor treatment plans for patients with ulcerative colitis, potentially improving their outcomes.
How similar studies have performed: Previous research has shown that Paneth cell characteristics can predict outcomes in Crohn's disease, suggesting a potential for success in similar applications for ulcerative colitis.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Liu, Ta-Chiang — Washington University
- Study coordinator: Liu, Ta-Chiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.