Using organoids to study and develop treatments for cancers
Organoids Core
This study is all about using tiny versions of organs made from real patient tissues to learn more about cancer and how it responds to different treatments, helping researchers find better ways to fight the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10891531 on NIH RePORTER |
What this research studies
This research focuses on creating and utilizing organoids, which are miniaturized and simplified versions of organs, to better understand cancer biology and treatment responses. Patient-derived organoids (PDOs) are developed from actual patient tissues, allowing researchers to observe how these organoids react to various drugs, mirroring the original patient's responses. The project aims to establish an Organoid Core that provides resources, expertise, and training to facilitate the use of organoids in cancer research, thereby overcoming barriers faced by individual laboratories. This initiative will enhance the ability to discover molecular targets and develop new therapies for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancers who are undergoing treatment or have provided tissue samples for organoid development.
Not a fit: Patients with non-cancerous conditions or those who do not have available tissue samples for organoid creation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments based on individual patient responses.
How similar studies have performed: Previous research has shown success in using organoids for drug response modeling, indicating that this approach is promising and has been validated in other studies.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Black, Adrian R — University of Nebraska Medical Center
- Study coordinator: Black, Adrian R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.