Using organoids to improve treatment for fatty liver disease
Organoid-guided Precision Hepatology for Steatohepatitis
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11030830
This study is looking at how certain genes might affect liver health in people with non-alcoholic fatty liver disease (NAFLD) by using special lab models, and it aims to find better ways to diagnose and treat this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11030830 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding non-alcoholic fatty liver disease (NAFLD) by utilizing innovative human organoids and gene editing technologies. By examining liver metabolism through personalized mechanisms, the study aims to identify genetic factors that contribute to liver inflammation and fat accumulation. Patients' tissues will be combined with engineered models to explore how specific genetic variants affect liver health, particularly under conditions of insulin resistance. The goal is to develop targeted diagnostic and therapeutic strategies for individuals affected by this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with non-alcoholic fatty liver disease, particularly those with genetic predispositions to liver inflammation.
Not a fit: Patients with liver diseases unrelated to fatty liver or those who do not have genetic risk factors for NAFLD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments for fatty liver disease, improving patient outcomes significantly.
How similar studies have performed: Previous research using organoids and genetic analysis has shown promise in understanding liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAKEBE, TAKANORI — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: TAKEBE, TAKANORI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, cell injury