Using organoids to improve treatment for fatty liver disease
Official title: Organoid-guided Precision Hepatology for Steatohepatitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11030830 · Data updated 2026-11-12
This study is looking at how certain genes might affect liver health in people with non-alcoholic fatty liver disease (NAFLD) by using special lab models, and it aims to find better ways to diagnose and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | February 15, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $530,803 |
| NIH project number | 5R01DK135478-02 |
| Project ID | NIH-11030830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with non-alcoholic fatty liver disease, particularly those with genetic predispositions to liver inflammation.
✕Less likely to help
Patients with liver diseases unrelated to fatty liver or those who do not have genetic risk factors for NAFLD may not benefit from this research.
What this research studies
This research focuses on understanding non-alcoholic fatty liver disease (NAFLD) by utilizing innovative human organoids and gene editing technologies. By examining liver metabolism through personalized mechanisms, the study aims to identify genetic factors that contribute to liver inflammation and fat accumulation. Patients' tissues will be combined with engineered models to explore how specific genetic variants affect liver health, particularly under conditions of insulin resistance. The goal is to develop targeted diagnostic and therapeutic strategies for individuals affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments for fatty liver disease, improving patient outcomes significantly.
How similar studies have gone: Previous research using organoids and genetic analysis has shown promise in understanding liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Takebe, Takanori — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Takebe, Takanori
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.