Using oral nicotine pouches to help reduce smoking-related cancer in Appalachia
Official title: Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer Disparities in Appalachia
Funded at Ohio State University · NIH-10855481 · Data updated 2026-11-12
This study is looking at whether using oral nicotine pouches can help adults in rural Appalachian areas cut down on smoking, and it involves 1,000 smokers trying out these pouches or other nicotine products to see which ones work better for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 4, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $661,139 |
| NIH project number | 1R01CA289551-01 |
| Project ID | NIH-10855481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult smokers living in rural Appalachian counties who are looking to quit smoking.
✕Less likely to help
Patients who do not smoke or are not interested in quitting smoking may not benefit from this research.
What this research studies
This research investigates the effectiveness of oral nicotine pouches as a tool to help reduce smoking rates among adults in rural Appalachian areas, where smoking-related cancer rates are alarmingly high. The study will involve a randomized trial with 1,000 adult smokers, who will be assigned to either use oral nicotine pouches or traditional nicotine replacement therapies. Participants will sample these products over a two-week period to assess their preferences and effectiveness in reducing smoking. The goal is to find a more acceptable and affordable alternative to cigarettes that can help improve health outcomes in this underserved region.
Why it matters
Potential benefit: If successful, this research could provide a new, effective method for reducing smoking rates and related cancer disparities in rural Appalachia.
How similar studies have gone: Previous research has shown that nicotine replacement therapies can be effective, but this approach using oral nicotine pouches is relatively novel and untested in this specific population.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Keller-Hamilton, Brittney L — Ohio State University
- Study coordinator: Keller-Hamilton, Brittney L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.