Using optical imaging to improve laser surgery for laryngeal cancer
Combination optical imaging to guide transoral laser microsurgery in larynx cancer
This study is testing a new way to help doctors see the edges of laryngeal tumors better during surgery, using a special imaging agent, so that patients with early-stage laryngeal cancer can have safer surgeries and a lower chance of the cancer coming back.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10946893 on NIH RePORTER |
What this research studies
This research aims to enhance transoral laser microsurgery (TLM) for laryngeal cancer by incorporating optical imaging techniques. The study will utilize a specific imaging agent, panitumumab-IRDye800, to help surgeons better visualize tumor borders during surgery, which is crucial for ensuring complete tumor removal while preserving healthy tissue. By addressing the limitations of current surgical methods, this research seeks to improve surgical outcomes and reduce the risk of cancer recurrence. Patients undergoing TLM for early-stage laryngeal tumors may benefit from this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage laryngeal cancer who are scheduled to undergo transoral laser microsurgery.
Not a fit: Patients with advanced laryngeal cancer or those not eligible for TLM may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical precision and better long-term outcomes for patients with laryngeal cancer.
How similar studies have performed: Previous studies have shown success with fluorescence-guided surgery in other cancer types, suggesting potential for similar benefits in laryngeal cancer.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Warram, Jason Morgan — University of Alabama at Birmingham
- Study coordinator: Warram, Jason Morgan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.