Using noninvasive vagus nerve stimulation to treat brain injuries
Noninvasive Vagus Nerve Stimulation for Treatment of Brain Injury (nVNS-TBI) in Rats
This study is looking at how a gentle electrical treatment on a nerve in the neck might help rats recover from brain injuries by reducing inflammation and improving brain function, which could be helpful for people who have had similar injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-10575817 on NIH RePORTER |
What this research studies
This research investigates the effects of noninvasive vagus nerve stimulation (nVNS) on brain injuries in a rat model. The approach involves delivering electrical impulses to the vagus nerve to activate the parasympathetic nervous system, which may help reduce inflammation and improve brain function after traumatic brain injury (TBI). The study aims to understand how nVNS can mitigate damage to the blood-brain barrier and enhance recovery from cognitive and motor impairments associated with TBI. Preliminary results suggest that nVNS may reduce brain lesion volume and anxiety, indicating potential therapeutic benefits.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals who have experienced a traumatic brain injury and are seeking innovative treatment options.
Not a fit: Patients with non-traumatic brain injuries or those who do not respond to vagus nerve stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from traumatic brain injuries.
How similar studies have performed: Previous clinical trials have shown success with noninvasive vagus nerve stimulation in treating conditions like migraines and PTSD, suggesting a promising avenue for TBI treatment.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Divani, Afshin Andre — University of New Mexico Health Scis Ctr
- Study coordinator: Divani, Afshin Andre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.