Using noninvasive tests to improve cancer treatment
Translation of Noninvasive Metabolic Biomarkers to Targeted Therapy for Cancer
This study is looking for ways to find out how cancer cells change their energy use, so doctors can create more personalized and effective treatments for cancer patients based on their individual needs.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11006303 on NIH RePORTER |
What this research studies
This research focuses on identifying noninvasive metabolic biomarkers that can help tailor targeted therapies for cancer patients. By analyzing how cancer cells alter their metabolism, particularly through a process known as the Warburg effect, the study aims to develop treatments that specifically address these metabolic changes. The approach involves monitoring levels of certain metabolites, like lactate and alanine, to determine the effectiveness of therapies that inhibit specific cancer-related proteins. Patients may benefit from more personalized and effective treatment options based on their unique metabolic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with mantle cell lymphoma or other cancers that exhibit the Warburg effect.
Not a fit: Patients with cancers that do not exhibit metabolic alterations or are not responsive to targeted therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer therapies that improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in using metabolic biomarkers to guide cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Nath, Kavindra — University of Pennsylvania
- Study coordinator: Nath, Kavindra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.