Using noninvasive brain stimulation to improve Alzheimer's disease in female mice
Noninvasive Neurostimulation to Reduce Pathology in a Female Mouse Model of Alzheimer's Disease
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-10869966
This study is looking at how a gentle light and sound treatment might help improve memory and learning in female mice with Alzheimer's, and it aims to find better ways to treat the disease by focusing on how it affects females differently.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (Decatur, UNITED STATES) |
| Trial ID | NIH-10869966 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of noninvasive audiovisual neurostimulation on Alzheimer's disease pathology in a female mouse model. The approach focuses on stimulating brain regions crucial for learning and memory, such as the hippocampus and prefrontal cortex, using a technique called gamma flicker. By targeting these areas, the study aims to enhance neural activity and potentially reverse cognitive impairments associated with Alzheimer's disease. The research emphasizes the importance of considering sex differences in Alzheimer's treatment development.
Who could benefit from this research
Good fit: Ideal candidates for this research are women at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those not exhibiting early cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new noninvasive treatment options for Alzheimer's disease that improve cognitive function.
How similar studies have performed: While this approach is innovative, similar noninvasive techniques have shown promise in other neurological conditions, suggesting potential for success in this context.
Where this research is happening
Decatur, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — Decatur, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRICHARD, ASHLEY — VETERANS HEALTH ADMINISTRATION
- Study coordinator: PRICHARD, ASHLEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome