Using nitric oxide to improve treatments for respiratory conditions and infections
Photochemical Generation of Gas Phase Nitric Oxide from Immobilized S-Nitrosothiols for Biomedical Applications
['FUNDING_SBIR_2'] · NOTA LABORATORIES, LLC · NIH-10708845
This study is looking at a new way to deliver nitric oxide, a helpful gas for treating breathing problems like high blood pressure in newborns and infections in people with cystic fibrosis or COPD, using a portable and affordable system that can be used at home or in hospitals, while also exploring its ability to fight antibiotic-resistant infections.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NOTA LABORATORIES, LLC (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10708845 on ClinicalTrials.gov |
What this research studies
This research focuses on the generation of nitric oxide (NO) from immobilized compounds for use in medical treatments. Nitric oxide is known for its roles in various bodily functions and has been shown to help with conditions like persistent pulmonary hypertension in newborns and respiratory infections in patients with cystic fibrosis and chronic obstructive pulmonary disease. The study aims to develop a portable and cost-effective system for delivering inhaled nitric oxide therapy, which could enhance patient care both in hospitals and at home. By exploring the antimicrobial properties of NO, the research seeks to address the challenges posed by antibiotic-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cystic fibrosis, chronic obstructive pulmonary disease, or those experiencing persistent pulmonary hypertension.
Not a fit: Patients with conditions unrelated to respiratory issues or those who do not require inhaled therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients with respiratory conditions and infections, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promising results for inhaled nitric oxide therapy in treating respiratory conditions, indicating a strong potential for success in this approach.
Where this research is happening
ANN ARBOR, UNITED STATES
- NOTA LABORATORIES, LLC — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOLF, ALEXANDER KEITH — NOTA LABORATORIES, LLC
- Study coordinator: WOLF, ALEXANDER KEITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.