Using nitric oxide-releasing compounds to improve healing of complex wounds
Official title: Nitric oxide-releasing glycosaminoglycans for treating complex wounds
Funded at Univ of North Carolina Chapel Hill · NIH-11002015 · Data updated 2026-11-12
This study is looking at new ways to help heal stubborn wounds, especially for people with diabetes, by using special materials that can release a helpful molecule to fight infections and support healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $343,284 |
| NIH project number | 5R01DK132778-03 |
| Project ID | NIH-11002015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic wounds, particularly those affected by diabetes or other conditions that impair healing.
✕Less likely to help
Patients with acute wounds or those not suffering from chronic conditions may not benefit from this research.
What this research studies
This research focuses on developing new treatments for chronic wounds that are slow to heal due to infections and inflammation, particularly in patients with conditions like diabetes. The approach involves creating glycosaminoglycan biopolymers that can release nitric oxide, a molecule that helps fight bacteria and modulate the immune response. By addressing both the infection and the underlying immune issues, this therapy aims to enhance the healing process for patients with complex wounds. The research will involve laboratory testing and potentially clinical trials to evaluate the effectiveness of these new compounds.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic wounds, reducing the risk of complications such as amputations.
How similar studies have gone: Previous research has shown promise in using nitric oxide for wound healing, suggesting that this approach could be a significant advancement in treatment.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Schoenfisch, Mark H — Univ of North Carolina Chapel Hill
- Study coordinator: Schoenfisch, Mark H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.