Using new small molecules to stabilize Axin for treating liver disease
Axin Stabilization by Novel Small Molecules to Treat Non-alcoholic Steatohepatitis
This study is looking at new small molecules that could help improve liver health for people with non-alcoholic steatohepatitis (NASH) by stabilizing a protein that helps manage liver metabolism and reducing fat buildup in the liver.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11012381 on NIH RePORTER |
What this research studies
This research focuses on developing new small molecules that can stabilize a protein called Axin, which plays a crucial role in liver metabolism. The study aims to target specific pathways involved in non-alcoholic steatohepatitis (NASH), a liver condition affecting many Americans. By inhibiting the Wnt/beta-catenin pathway and activating AMPK, the researchers hope to improve liver health and reduce fat accumulation in the liver. The compounds being tested have shown promising results in laboratory and animal models, indicating their potential effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis or related metabolic disorders.
Not a fit: Patients with alcoholic liver disease or those without metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for non-alcoholic steatohepatitis, improving liver health for many patients.
How similar studies have performed: Previous research has shown success in targeting similar pathways for liver diseases, suggesting a promising avenue for this approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Shu, Yan — University of Maryland Baltimore
- Study coordinator: Shu, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.