Using new biomarkers to predict early pregnancy failure
Official title: Clinical utility of novel biomarkers for prediction of early pregnancy failure
Funded at University of Pennsylvania · NIH-11017851 · Data updated 2026-11-12
This study is looking to help women who might be at risk for ectopic pregnancy or miscarriage by finding new ways to predict early pregnancy outcomes using special markers, making it easier and less stressful for them to get accurate information without needing invasive tests.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $669,511 |
| NIH project number | 5R01HD110448-03 |
| Project ID | NIH-11017851 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women in their first trimester who are at risk for ectopic pregnancy or spontaneous abortion.
✕Less likely to help
Patients who are not in their first trimester or those without risk factors for early pregnancy complications may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis and management of women at risk for ectopic pregnancy and spontaneous abortion by utilizing novel biomarkers. The study aims to validate a set of biomarkers that can accurately predict the location and viability of early pregnancies, reducing the need for invasive procedures and minimizing misdiagnosis. By employing machine learning techniques, the researchers have identified specific biomarkers that can provide high accuracy in predicting pregnancy outcomes. This approach seeks to alleviate the stress and uncertainty faced by women during early pregnancy assessments.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and less invasive methods for diagnosing early pregnancy complications, ultimately improving patient care.
How similar studies have gone: Previous research has shown promising results using similar biomarker approaches, indicating potential for success in this novel application.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Barnhart, Kurt T — University of Pennsylvania
- Study coordinator: Barnhart, Kurt T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.