Using neural stem cells to treat multiple sclerosis in mice
Efficacy of NSCs in an EAE model of MS
This study is exploring whether giving neural stem cells to mice with a condition similar to multiple sclerosis can help improve their symptoms, with the hope that this treatment could one day benefit people with MS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11094799 on NIH RePORTER |
What this research studies
This research investigates the potential of neural stem cells (NSCs) to treat multiple sclerosis (MS) by using a mouse model of the disease. The study aims to determine the therapeutic effects of administering multiple doses of NSCs to improve symptoms of chronic experimental autoimmune encephalomyelitis (EAE), which mimics MS. By isolating and differentiating primitive mesenchymal stem cells into NSCs, the researchers hope to enhance the effectiveness of cell therapy for MS. The approach is based on promising preliminary results showing that a single dose of NSCs significantly improved clinical symptoms in mice.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing chronic symptoms.
Not a fit: Patients with advanced stages of multiple sclerosis or those who do not respond to cell-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel and effective treatment for multiple sclerosis, potentially reducing symptoms and improving quality of life for patients.
How similar studies have performed: Previous research has shown some success with cell therapies in treating MS, but this approach using NSCs is innovative and has not been extensively tested.
Where this research is happening
Rochester, United States
- Oakland University — Rochester, United States (Active)
Researchers
- Principal investigator: Chaudhry, G. Rasul — Oakland University
- Study coordinator: Chaudhry, G. Rasul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.