Using neural stem cells to treat multiple sclerosis in mice
Official title: Efficacy of NSCs in an EAE model of MS
Funded at Oakland University · NIH-11094799 · Data updated 2026-11-12
This study is exploring whether giving neural stem cells to mice with a condition similar to multiple sclerosis can help improve their symptoms, with the hope that this treatment could one day benefit people with MS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 15, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $150,000 |
| NIH project number | 5R16NS129748-04 |
| Project ID | NIH-11094799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing chronic symptoms.
✕Less likely to help
Patients with advanced stages of multiple sclerosis or those who do not respond to cell-based therapies may not benefit from this research.
What this research studies
This research investigates the potential of neural stem cells (NSCs) to treat multiple sclerosis (MS) by using a mouse model of the disease. The study aims to determine the therapeutic effects of administering multiple doses of NSCs to improve symptoms of chronic experimental autoimmune encephalomyelitis (EAE), which mimics MS. By isolating and differentiating primitive mesenchymal stem cells into NSCs, the researchers hope to enhance the effectiveness of cell therapy for MS. The approach is based on promising preliminary results showing that a single dose of NSCs significantly improved clinical symptoms in mice.
Why it matters
Potential benefit: If successful, this research could lead to a novel and effective treatment for multiple sclerosis, potentially reducing symptoms and improving quality of life for patients.
How similar studies have gone: Previous research has shown some success with cell therapies in treating MS, but this approach using NSCs is innovative and has not been extensively tested.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Chaudhry, G. Rasul — Oakland University
- Study coordinator: Chaudhry, G. Rasul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.