Using network medicine to improve treatment for pulmonary hypertension related to heart failure
Network Medicine and Systems Pharmacology to Advance Precision Medicine in Combined Pulmonary Hypertension
This study is looking at how to better understand and treat pulmonary hypertension caused by left heart failure, by examining the unique biological traits of patients to create personalized treatment plans that could improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11089322 on NIH RePORTER |
What this research studies
This research focuses on understanding pulmonary hypertension (PH) that occurs due to left heart failure, a condition that can severely impact patients' lives. By analyzing the unique biological and genetic profiles of patients with combined pre- and post-capillary PH, the research aims to develop personalized treatment strategies. The approach involves creating patient-specific molecular networks that map protein interactions, which could lead to better diagnostic tools and targeted therapies. This innovative methodology seeks to address the current lack of effective biomarkers and treatments for this complex condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension due to left heart failure, particularly those with combined pre- and post-capillary PH.
Not a fit: Patients with pulmonary hypertension not related to left heart failure or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients suffering from pulmonary hypertension related to heart failure.
How similar studies have performed: Other research has shown promise in using network medicine approaches for complex diseases, suggesting potential for success in this novel application.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Brittain, Evan L — Vanderbilt University Medical Center
- Study coordinator: Brittain, Evan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.