Using nanotechnology to improve immune treatment for lymphoma
Official title: Local nano-immune modulation for the systemic treatment of lymphoma
Funded at Northwestern University at Chicago · NIH-10884825 · Data updated 2026-11-12
This study is testing a new treatment that uses tiny gold particles and light to help your immune system fight back against tough-to-treat B cell lymphomas, and it’s looking for patients to see how well it works compared to standard therapies.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $275,837 |
| NIH project number | 1K08CA283285-01A1 |
| Project ID | NIH-10884825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with relapsed or refractory B cell lymphomas who have not responded well to standard therapies.
✕Less likely to help
Patients with early-stage lymphoma or those who have not yet undergone treatment may not benefit from this research.
What this research studies
This research investigates a novel therapy that combines immune-based nanotechnology with photothermal therapy to enhance treatment for relapsed or refractory B cell lymphomas. The approach aims to modify both local and systemic immune environments to improve the effectiveness of existing immunotherapies, which often struggle due to suppressive tumor conditions. By utilizing specially designed gold nanoparticles activated by near-infrared light, the therapy seeks to generate a robust T-cell response against lymphoma cells. Patients may be involved in evaluating how well this new treatment works compared to traditional methods.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with difficult-to-treat lymphomas, potentially improving survival rates and quality of life.
How similar studies have gone: While the use of photothermal therapy in solid tumors has shown promise, this specific application in lymphoma is novel and has not been extensively tested.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Lin, Adam Yuh — Northwestern University at Chicago
- Study coordinator: Lin, Adam Yuh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.