Using nanosecond electric fields to control nerve activity
Targeted Neuromodulation by Nanosecond Pulsed Electric Fields
['FUNDING_R21'] · OLD DOMINION UNIVERSITY · NIH-10903751
This study is testing a new way to gently control nerve activity using short bursts of electricity, which could help treat neurological conditions and tumors without the usual side effects of traditional methods, and it's designed for people looking for safer outpatient treatment options.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OLD DOMINION UNIVERSITY (nih funded) |
| Locations | 1 site (NORFOLK, UNITED STATES) |
| Trial ID | NIH-10903751 on ClinicalTrials.gov |
What this research studies
This research explores a novel technique called nanosecond pulsed electric fields (nsPEF) for neuromodulation, which allows for precise control of nerve activity without the side effects associated with traditional electrostimulation. By applying these electric fields, researchers aim to stimulate, inhibit, or even ablate specific cells non-invasively, making it a potential outpatient treatment option. The study employs advanced imaging techniques to monitor changes in cell membrane potential in real-time, providing insights into how these electric fields affect cellular behavior. This innovative approach could lead to new therapies for various neurological conditions and tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with neurological conditions or tumors that may benefit from non-invasive neuromodulation techniques.
Not a fit: Patients with conditions that do not involve nerve activity or tumors may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for neurological disorders and tumors.
How similar studies have performed: While the use of electric fields for neuromodulation is a relatively novel approach, preliminary studies have shown promising results in related areas.
Where this research is happening
NORFOLK, UNITED STATES
- OLD DOMINION UNIVERSITY — NORFOLK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAKHOMOV, ANDREI G — OLD DOMINION UNIVERSITY
- Study coordinator: PAKHOMOV, ANDREI G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.