Using nanoparticles to reduce oxidative stress in osteoarthritis
Official title: ROS scavenging nanoparticles for mitigating oxidative stress in osteoarthritis
Funded at University of Florida · NIH-11030283 · Data updated 2026-11-12
This study is looking at a new way to help people with osteoarthritis by using tiny particles that can deliver antioxidants directly to the joints, aiming to reduce pain and improve joint health more effectively than current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | February 23, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $417,308 |
| NIH project number | 5R01AR080687-03 |
| Project ID | NIH-11030283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with osteoarthritis who experience symptoms related to oxidative stress in their joints.
✕Less likely to help
Patients with osteoarthritis who do not exhibit significant oxidative stress or those with advanced joint degeneration may not benefit from this research.
What this research studies
This research investigates the use of manganese dioxide nanoparticles to target and reduce oxidative stress in the joints of patients with osteoarthritis. By enhancing the stability and bioavailability of antioxidants, these nanoparticles aim to provide prolonged therapeutic effects directly within joint tissues. The approach focuses on overcoming the limitations of traditional antioxidant treatments, which often fail due to rapid clearance from the body. The study will explore how these engineered nanoparticles can improve joint health and alleviate symptoms associated with osteoarthritis.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for osteoarthritis, potentially reducing pain and improving joint function for patients.
How similar studies have gone: Previous research has shown promise in using nanoparticles for targeted drug delivery in various conditions, indicating potential success for this novel approach in osteoarthritis.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Sharma, Blanka — University of Florida
- Study coordinator: Sharma, Blanka
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.