Using nanoparticles to improve treatment for severe inflammation and sepsis
Official title: Multimodal Nanoparticles for Severe Inflammation and Sepsis
Funded at University of Maryland Baltimore · NIH-11202126 · Data updated 2026-11-12
This study is exploring a new treatment using tiny particles to help boost the immune system in people with sepsis, a serious infection-related condition, with the hope of improving survival and reducing complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 21, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $684,206 |
| NIH project number | 1R01AI192405-01 |
| Project ID | NIH-11202126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with severe sepsis or septic shock who are experiencing an uncontrolled immune response to infection.
✕Less likely to help
Patients with mild infections or those who do not meet the criteria for severe sepsis may not benefit from this research.
What this research studies
This research focuses on developing a new type of immunotherapy using nanoparticles to enhance the immune response in patients suffering from sepsis, a severe and life-threatening condition caused by infections. The approach involves creating drug-free nanoparticles that can modulate the immune system to improve survival rates and reduce complications associated with sepsis. By testing these nanoparticles in animal models, the researchers aim to understand their effectiveness and safety before considering human trials. Patients may benefit from a more effective treatment option that addresses the complex nature of sepsis.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that significantly improves survival rates and reduces long-term complications for patients with sepsis.
How similar studies have gone: Previous research has shown promising results with nanoparticle-based therapies in other inflammatory conditions, suggesting potential for success in this novel application.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Pearson, Ryan Matthew — University of Maryland Baltimore
- Study coordinator: Pearson, Ryan Matthew
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.