Using nanoparticles to improve treatment for fluid buildup in lung cancer patients
Intrapleural immunotherapeutic nanoparticles for MPE treatment
This study is testing a new way to help lung cancer patients with fluid buildup in their chest by using tiny particles that boost the immune system to fight the cancer better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10890019 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treat malignant pleural effusion (MPE), a condition often seen in late-stage lung cancer patients. The study focuses on using intrapleural immunotherapeutic nanoparticles that aim to enhance the immune response against cancer cells by targeting the tumor immune microenvironment. By utilizing a specific pathway known as the STING pathway, the treatment seeks to activate the body's immune system to better fight the cancer. Patients may receive these nanoparticles directly into the pleural space, potentially improving their overall treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who are experiencing malignant pleural effusion.
Not a fit: Patients with early-stage lung cancer or those without malignant pleural effusion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option that enhances immune response and improves survival rates for patients with malignant pleural effusion.
How similar studies have performed: Previous research has shown some success with immunotherapeutic approaches in similar contexts, but this specific application of nanoparticles is relatively novel.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Zhao, Dawen — Wake Forest University Health Sciences
- Study coordinator: Zhao, Dawen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.