Using nanoparticles to enhance immune responses against brain tumors
Photothermal Nanoparticles Immune Engineer Tumor-specific T cells for Adoptive Cell Therapy
['FUNDING_R01'] · GEORGE WASHINGTON UNIVERSITY · NIH-11065502
This study is exploring a new way to help your immune system fight glioblastoma, a type of brain cancer, by using special particles to boost your own tumor cells and create a personalized treatment just for you after surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGE WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11065502 on ClinicalTrials.gov |
What this research studies
This research investigates a new method using photothermal nanoparticles to create tumor-specific T cells for treating glioblastoma, a type of brain cancer. The approach involves taking tumor cells from patients after surgery and treating them with these nanoparticles to enhance their ability to stimulate the immune system. The treated tumor cells are then combined with immune cells from the patient or a matched donor to generate a personalized therapy aimed at improving patient outcomes. This therapy is intended for patients who have undergone standard treatments and are in a state of minimal residual disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who have undergone surgery and are in a minimally residual disease state.
Not a fit: Patients with advanced glioblastoma or those who have not undergone surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates for patients.
How similar studies have performed: Previous studies have shown promising results using similar nanoparticle approaches to enhance immune responses in cancer therapy.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGE WASHINGTON UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERNANDES, ROHAN — GEORGE WASHINGTON UNIVERSITY
- Study coordinator: FERNANDES, ROHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.