Using nanodiscs to improve MRI imaging for cell therapies
Official title: Nanodisc Platform for 19F-MRI
Funded at University of California at Davis · NIH-10885150 · Data updated 2026-11-12
This study is testing a new type of tiny particles called nanodiscs to help doctors see small groups of cells more clearly during MRI scans, which could make it easier to track treatments for different diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | July 11, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $212,201 |
| NIH project number | 5R21EB033689-02 |
| Project ID | NIH-10885150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing cell therapy for conditions such as cancer, particularly those who may benefit from improved imaging techniques.
✕Less likely to help
Patients who are not receiving cell therapies or those with conditions that do not require advanced imaging techniques may not benefit from this research.
What this research studies
This research focuses on developing a new type of contrast agent for MRI imaging that utilizes nanodiscs, which are tiny particles designed to enhance the visibility of small groups of cells during imaging. Traditional MRI methods often struggle to track these cells effectively, but the innovative use of nanodiscs aims to provide clearer images by avoiding nonspecific uptake by immune cells. The study will explore how these nanodiscs can be used to target specific biomarkers, potentially improving the monitoring of cell therapies in various diseases. By creating smaller contrast agents, the research seeks to enhance the accuracy of molecular imaging techniques.
Why it matters
Potential benefit: If successful, this research could lead to more precise monitoring of cell therapies, improving treatment outcomes for patients with conditions like cancer.
How similar studies have gone: Previous studies have shown promise in using novel imaging techniques for cell tracking, but the specific application of nanodiscs in 19F-MRI is a relatively new and untested approach.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Louie, Angelique Y — University of California at Davis
- Study coordinator: Louie, Angelique Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.