Using nanobubbles to deliver oxygen during cardiac arrest and organ ischemia
Official title: Nanobubble oxygenation in cardiac arrest and acute vital organ ischemia
Funded at University of Minnesota · NIH-11076250 · Data updated 2026-11-12
This study is exploring a new way to deliver oxygen directly into the bloodstream using a special mixture of saline and oxygen, which could help people in emergencies like cardiac arrest by keeping their organs safe until more treatment can be given.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 17, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $678,487 |
| NIH project number | 5R01HL169329-02 |
| Project ID | NIH-11076250 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing cardiac arrest or severe oxygen deprivation, particularly in emergency medical situations.
✕Less likely to help
Patients who are not experiencing acute oxygen deprivation or cardiac events may not benefit from this research.
What this research studies
This research investigates a novel method of delivering oxygen directly into the bloodstream using a highly pressurized saline and oxygen mixture. By infusing this solution during critical situations like cardiac arrest, the goal is to improve oxygen levels in the blood, which can help protect vital organs from damage. The approach aims to sustain oxygen requirements for a short period, potentially buying time for more definitive medical interventions. This could be particularly beneficial in emergency settings where traditional oxygen delivery methods are not effective.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and outcomes for patients experiencing cardiac arrest or acute organ ischemia.
How similar studies have gone: While the concept of direct intravenous gas delivery has been traditionally viewed as risky, this innovative approach is exploring untested methods that could lead to significant advancements in emergency care.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Yannopoulos, Demetris — University of Minnesota
- Study coordinator: Yannopoulos, Demetris
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.