Using Naltrexone and real-time support to help reduce methamphetamine use in MSM
The ION+EMI Study: Intermittent Oral Naltrexone enhanced with an Ecological Momentary Intervention for Methamphetamine-using MSM
This study is looking at whether taking a medication called naltrexone, along with real-time support through a special app, can help men who have sex with men and are living with HIV cut down on their methamphetamine use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10670945 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of intermittent oral naltrexone, combined with an ecological momentary intervention (EMI), to help reduce methamphetamine use among men who have sex with men (MSM), particularly those living with HIV. The approach involves providing real-time support and interventions tailored to the individual's context, which may help improve adherence to treatment and reduce risky behaviors associated with meth use. Participants will receive naltrexone, a medication that blocks the effects of opioids, which has shown promise in reducing relapse to methamphetamine use. The study aims to fill a significant gap in effective treatments for methamphetamine use in this high-risk population.
Who could benefit from this research
Good fit: Ideal candidates for this research are men who have sex with men (MSM) aged 21 and older who are currently using methamphetamine and may also be living with HIV.
Not a fit: Patients who do not use methamphetamine or who are not part of the MSM community may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new effective treatment option for reducing methamphetamine use and improving health outcomes for MSM, particularly those living with HIV.
How similar studies have performed: While there is limited research specifically on the combination of naltrexone and EMI for methamphetamine use, similar interventions have shown promise in other substance use contexts.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Santos, Glenn-Milo — University of California, San Francisco
- Study coordinator: Santos, Glenn-Milo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.