Using mRNA technology to deliver targeted antimicrobial treatments
Harnessing mRNA Vaccine Technology for Precision Antimicrobial Delivery
This study is exploring a new way to fight tough bacterial infections, especially those that don't respond to regular antibiotics, by using a special technology that helps your body make proteins to target and eliminate harmful bacteria.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Phase Genomics, INC. NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11186644 on NIH RePORTER |
What this research studies
This research investigates a novel approach to combat antimicrobial resistance (AMR) by utilizing mRNA technology to deliver endolysin proteins that specifically target harmful bacteria. The study focuses on developing a delivery system that uses self-replicating mRNA encapsulated in lipid nanoparticles, which can produce these proteins in the body for an extended period. By targeting specific bacteria like vancomycin-resistant Enterococcus faecium (VRE), this method aims to provide a more effective alternative to traditional antibiotics, which often lead to resistance. Patients may benefit from a more effective treatment option that can clear bacterial infections without contributing to resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections caused by non-bacterial pathogens or those who do not have antibiotic-resistant infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with a new, effective treatment for antibiotic-resistant infections.
How similar studies have performed: While the use of mRNA technology in vaccines has shown significant success, the application of this technology for antimicrobial delivery is relatively novel and untested.
Where this research is happening
Seattle, United States
- Phase Genomics, INC. — Seattle, United States (Active)
Researchers
- Principal investigator: Liachko, Ivan — Phase Genomics, INC.
- Study coordinator: Liachko, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.