Using mRNA-based materials to help repair damaged nerves
mRNA-containing fibrous conduits for repair of long-gap peripheral nerve injury
This study is exploring a new way to help heal serious nerve injuries, especially for veterans, by using special materials that support nerve cell growth without needing traditional grafts, making recovery easier and more effective.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stratton Veterans Admin Medical Center NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-11249111 on NIH RePORTER |
What this research studies
This research focuses on developing innovative fibrous conduits made from mRNA-containing materials to repair long-gap peripheral nerve injuries, which are common among veterans and others. The approach involves creating biodegradable scaffolds that can support the growth of nerve cells and promote healing without the need for traditional nerve grafts, which can cause additional complications. By utilizing electrospun fibers, the study aims to enhance axonal regeneration and improve recovery outcomes for patients with severe nerve damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from long-gap peripheral nerve injuries, particularly veterans who may have limited options for traditional nerve repair.
Not a fit: Patients with short-gap nerve injuries or those who do not have peripheral nerve damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for nerve injuries, reducing recovery time and improving functional outcomes for patients.
How similar studies have performed: Previous research has shown promise in using biomaterial conduits for nerve repair, but this specific approach utilizing mRNA-based materials is relatively novel.
Where this research is happening
Albany, United States
- Stratton Veterans Admin Medical Center — Albany, United States (Active)
Researchers
- Principal investigator: Gilbert, Ryan J. — Stratton Veterans Admin Medical Center
- Study coordinator: Gilbert, Ryan J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.