Using MRI to measure kidney fibrosis noninvasively
Official title: Fibrosis Beyond the Core: A New Application of MRI to Noninvasively Quantify Whole Kidney Fibrosis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10796499 · Data updated 2026-11-12
This study is testing a new MRI method to help doctors see and measure kidney scarring in people with chronic kidney disease, which could improve how we track the disease and the success of new treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $337,283 |
| NIH project number | 1R21DK133562-01A1 |
| Project ID | NIH-10796499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing chronic kidney disease.
✕Less likely to help
Patients with acute kidney injury or those without any signs of kidney disease may not benefit from this research.
What this research studies
This research focuses on developing a new MRI technique to noninvasively detect and quantify kidney fibrosis, which is a critical factor in the progression of chronic kidney disease (CKD). The study aims to implement a fast 3D radial MRI imaging method that can accurately capture signals from amide protons found in collagen, which accumulates in fibrotic kidneys. By improving the ability to monitor kidney fibrosis, this research could help in assessing disease progression and the effectiveness of new treatments for CKD.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of chronic kidney disease and better monitoring of treatment responses, ultimately improving patient outcomes.
How similar studies have gone: Other research has shown promise in using advanced MRI techniques for similar applications, indicating potential for success in this novel approach.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Lindquist, Diana M — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Lindquist, Diana M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.