Using MRI to measure brain oxygen levels in Alzheimer's disease
MRI assessment of cerebral oxygen extraction fraction (OEF) in the medial temporal lobe as a biomarker in Alzheimer's disease
This study is looking at how MRI can help measure oxygen use in a part of the brain important for memory, to see if it can spot early signs of Alzheimer's disease, which could help people get the right care sooner.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10523185 on NIH RePORTER |
What this research studies
This research investigates the use of MRI to measure the oxygen extraction fraction (OEF) in the medial temporal lobe, a brain region crucial for memory, as a potential early biomarker for Alzheimer's disease. By focusing on brain function rather than structural changes, the study aims to identify early signs of Alzheimer's that could lead to more timely and effective interventions. The approach involves advanced MRI techniques to quantify OEF, which reflects the brain's energy metabolism and neural activity. This could provide a more sensitive and specific method for diagnosing Alzheimer's compared to traditional structural imaging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing early symptoms of cognitive decline or have a family history of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those who do not exhibit any cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, allowing for timely treatment and management.
How similar studies have performed: Previous studies have shown that measuring global oxygen extraction is sensitive to Alzheimer's disease, suggesting that localized measurements could enhance diagnostic capabilities.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Lu, Hanzhang — Johns Hopkins University
- Study coordinator: Lu, Hanzhang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.