Using MRI to improve monitoring of myelofibrosis treatment
Official title: Development of quantitative bone marrow magnetic resonance imaging biomarkers to assess efficacy of novel molecularly targeted agents for myelofibrosis
Funded at University of Michigan at Ann Arbor · NIH-11018856 · Data updated 2026-11-12
This study is exploring new MRI methods to help doctors see how well treatments are working for people with myelofibrosis, a type of blood cancer, without needing painful procedures like biopsies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $647,398 |
| NIH project number | 1R01CA297995-01 |
| Project ID | NIH-11018856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with myelofibrosis who are undergoing treatment.
✕Less likely to help
Patients who do not have myelofibrosis or are not receiving treatment for this condition may not benefit from this research.
What this research studies
This research focuses on developing advanced MRI techniques to create noninvasive biomarkers for assessing the effectiveness of new treatments for myelofibrosis, a serious blood cancer. By utilizing specialized MRI sequences, the study aims to capture detailed changes in bone marrow that reflect the disease's progression and response to therapy. This approach seeks to overcome the limitations of current methods, such as painful biopsies and slow changes in spleen size, providing a more comprehensive view of patient health.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely assessments of treatment efficacy for patients with myelofibrosis.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for monitoring other hematological conditions, suggesting potential success for this novel approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Ross, Brian D. — University of Michigan at Ann Arbor
- Study coordinator: Ross, Brian D.
Related research
Other NIH-funded projects on the same topics.
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MRI markers to monitor bone marrow in myelofibrosis
Advanced MRI scans will be used to see bone marrow changes in people with myelofibrosis so doctors can tell sooner whether new targeted drugs are working.
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Systemic imaging probes for detecting tissue oxygen levels in cancer and other diseases
A researcher aims to develop a new europium-based MRI contrast agent that can be given systemically to visualize oxygen levels (hypoxia) in cancer and other diseases.
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Improving deep brain stimulation with MRI and AI
We use brain scans and artificial intelligence to speed up and personalize deep brain stimulation settings for people getting DBS.
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Strategies to deplete myelofibrosis stem cells using HDM2/p53 pathway
A patient-focused program tests a therapy that may selectively reduce disease-causing blood stem cells in people with myelofibrosis.
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Megakaryocyte changes in myelofibrosis and its progression to leukemia
A scientist-guided project will study how abnormal megakaryocytes and signals like TGF-β and IL-13 may drive progression from myelofibrosis toward acute leukemia, with potential implications for future treatments.
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Molecular clues and new therapies for myelofibrosis and related blood cancers
This grant supports research to understand what drives myelofibrosis and related disorders and to develop new treatment ideas for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.