Using MRI to improve monitoring of myelofibrosis treatment
Development of quantitative bone marrow magnetic resonance imaging biomarkers to assess efficacy of novel molecularly targeted agents for myelofibrosis
This study is exploring new MRI methods to help doctors see how well treatments are working for people with myelofibrosis, a type of blood cancer, without needing painful procedures like biopsies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11018856 on NIH RePORTER |
What this research studies
This research focuses on developing advanced MRI techniques to create noninvasive biomarkers for assessing the effectiveness of new treatments for myelofibrosis, a serious blood cancer. By utilizing specialized MRI sequences, the study aims to capture detailed changes in bone marrow that reflect the disease's progression and response to therapy. This approach seeks to overcome the limitations of current methods, such as painful biopsies and slow changes in spleen size, providing a more comprehensive view of patient health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with myelofibrosis who are undergoing treatment.
Not a fit: Patients who do not have myelofibrosis or are not receiving treatment for this condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely assessments of treatment efficacy for patients with myelofibrosis.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for monitoring other hematological conditions, suggesting potential success for this novel approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Ross, Brian D. — University of Michigan at Ann Arbor
- Study coordinator: Ross, Brian D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.