Using MRI to guide cryotherapy and deliver immune therapy for treating canine osteosarcoma
Official title: MRI-Guided Cryoablation and Imaging-Guided Intratumoral Delivery of STING Agonist Immunotherapy to Target Localized and Metastatic Canine Osteosarcoma
Funded at Johns Hopkins University · NIH-10835961 · Data updated 2026-11-12
This study is testing a new way to treat osteosarcoma in dogs by using a special cooling technique to freeze the tumor and then giving an injection to help the dog's immune system fight any leftover cancer cells, all to help improve the health of dogs with this tough cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $596,467 |
| NIH project number | 5R01CA239124-05 |
| Project ID | NIH-10835961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are dogs diagnosed with non-metastatic appendicular osteosarcoma.
✕Less likely to help
Dogs with metastatic osteosarcoma or other unrelated health issues may not benefit from this research.
What this research studies
This research focuses on developing a new treatment for osteosarcoma (OSA) in dogs by combining MRI-guided cryotherapy with the injection of an immune-boosting agent directly into the tumor. The approach aims to not only destroy the tumor cells but also stimulate the dog's immune system to recognize and attack any remaining cancer cells. By conducting a clinical trial on dogs with non-metastatic OSA, the researchers will gather important data on how these therapies work together and their effects on the immune response. This innovative method seeks to improve outcomes for dogs suffering from this aggressive cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for canine osteosarcoma, potentially improving survival rates and quality of life for affected dogs.
How similar studies have gone: While this approach is innovative, similar strategies combining cryotherapy and immunotherapy have shown promise in other cancer types, suggesting potential for success in this context.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kraitchman, Dara L — Johns Hopkins University
- Study coordinator: Kraitchman, Dara L
Related research
Other NIH-funded projects on the same topics.
-
Using engineered natural killer cells to treat bone cancer
This study is testing a new treatment for bone cancer called osteosarcoma by using specially modified immune cells that can better find and kill cancer cells, aiming to offer a safer and more effective option for patients.
-
Investigating new immunotherapy options for osteosarcoma
This study is looking at new ways to help the immune system fight osteosarcoma, a type of bone cancer, by using special treatments like CAR T cells and oncolytic viruses, with the goal of making things better for patients dealing with this condition.
-
Boosting immune response to fight cancer
This study is exploring a new way to help your immune system better fight cancer by tweaking certain cells in your body, and it aims to improve treatment for people with advanced cancer.
-
A center focused on immunotherapy for pediatric cancers.
This study is exploring new ways to use the body's immune system to fight childhood cancers, aiming to create better treatments for kids whose cancers haven't responded well to standard therapies.
-
Algorithms to find HLA-E neoantigens for cancer immunotherapy
Aims to develop computer methods to discover tumor-specific targets presented by HLA-E to guide new T cell therapies for cancer.
-
Immunotherapy for glioblastoma: advancing treatment and understanding
A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.