Using MRI to find hidden carotid plaques that may cause unexplained strokes
MRI Detection of CarotId Plaques as a mecHanism for Embolic strokes of undeteRmined source (MRI DECIPHER)
This study is looking at hidden plaques in the carotid arteries that might cause strokes without a clear reason, using advanced MRI technology to find out which ones could be dangerous, especially for people who have had unexplained strokes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10661676 on NIH RePORTER |
What this research studies
This research investigates the role of unrecognized atherosclerotic plaques in the carotid arteries as potential causes of strokes that currently have no identifiable source. By utilizing advanced magnetic resonance imaging (MRI), the study aims to identify high-risk nonstenosing plaques that could rupture and lead to clots blocking blood flow to the brain. The approach focuses on understanding the relationship between these plaques and stroke occurrence, particularly in patients with strokes of unknown origin. If successful, this research could enhance the detection of these plaques and improve patient outcomes through better-targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke of undetermined cause, particularly those with risk factors for atherosclerosis.
Not a fit: Patients who have strokes with clearly identifiable causes or those without any history of vascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of patients at risk for strokes caused by hidden carotid plaques.
How similar studies have performed: Previous pilot studies have shown promising results in identifying high-risk nonstenosing plaques as potential contributors to unexplained strokes, suggesting that this approach may be effective.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Kamel, Hooman — Weill Medical Coll of Cornell Univ
- Study coordinator: Kamel, Hooman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.