Using MRI reporter genes to monitor gene therapy and cancer treatments
Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and Sensitivity
This study is working on a new way to use MRI scans to see how well gene therapies are working in real-time, which could help patients get better treatments and outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11046995 on NIH RePORTER |
What this research studies
This research focuses on developing advanced MRI reporter genes that can non-invasively track gene expression in real-time with high resolution. It aims to improve the monitoring of gene therapies and oncolytic virotherapy by overcoming current challenges related to sensitivity and specificity in detection. The approach utilizes a lysine-rich protein reporter gene detectable by a specialized MRI technique, which enhances the ability to assess cellular activities and treatment efficacy. Patients may benefit from more precise monitoring of their treatments and better outcomes through improved therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates include patients undergoing gene therapy or oncolytic virotherapy for cancer.
Not a fit: Patients not involved in gene therapy or those with conditions not related to cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring of cancer treatments and gene therapies, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using MRI reporter genes, but this approach aims to address specific limitations that have not yet been fully resolved.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Farrar, Christian T — Massachusetts General Hospital
- Study coordinator: Farrar, Christian T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.