Using mouse models to improve treatment for idiopathic pulmonary fibrosis
Official title: Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary Fibrosis
Funded at University of Pennsylvania · NIH-10754510 · Data updated 2026-11-12
This study is looking at a serious lung disease called idiopathic pulmonary fibrosis (IPF) in older adults by creating special mouse models to help us learn how certain gene changes affect the disease, with the hope of finding new treatments to help people with IPF feel better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $765,307 |
| NIH project number | 5U01HL152970-04 |
| Project ID | NIH-10754510 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with idiopathic pulmonary fibrosis or those with a family history of the disease.
✕Less likely to help
Patients with other forms of lung disease unrelated to idiopathic pulmonary fibrosis may not benefit from this research.
What this research studies
This research focuses on idiopathic pulmonary fibrosis (IPF), a serious lung disease affecting older adults, by developing advanced mouse models that mimic the disease. These models will help researchers understand how mutations in a specific gene related to lung function contribute to IPF and its progression. By studying these models, the research aims to identify new therapeutic strategies that could lead to better treatment options for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with idiopathic pulmonary fibrosis.
How similar studies have gone: Previous research has shown promise in using similar mouse models to advance understanding and treatment of lung diseases, indicating a potential for success in this approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Beers, Michael Francis — University of Pennsylvania
- Study coordinator: Beers, Michael Francis
Related research
Other NIH-funded projects on the same topics.
-
Repurposing Pyrvinium as an Inhaled Therapy for Idiopathic Pulmonary Fibrosis
A patient-friendly look at a project trying to use an existing drug, pyrvinium, as an inhaled treatment option for idiopathic pulmonary fibrosis (IPF).
-
Screening new compounds to reverse gene signatures in IPF lungs
A researcher hopes to find compounds that reverse harmful gene changes in the lungs of people with idiopathic pulmonary fibrosis (IPF).
-
Unraveling IPF subtypes to guide prognosis and therapy
This grant aims to identify different IPF subtypes in the lung to improve how we predict outcomes and tailor treatments for people with IPF.
-
Novel antibody therapy to treat idiopathic pulmonary fibrosis
A small business gig is developing a targeted antibody drug (VSR-H5) to treat idiopathic pulmonary fibrosis in patients, aiming for better safety and effectiveness than current medicines.
-
Repurposing Vonoprazan as an inhaled therapy for IPF
A high-profile NIH grant is testing whether an existing drug, vonoprazan, can be inhaled to slow or reverse lung fibrosis in people with idiopathic pulmonary fibrosis (IPF).
-
Proteomic profile of IPF progression to help tailor treatments
A study will look for blood protein patterns that predict how IPF lung disease will progress in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.