Using modified T cells to fight HIV directly in the body
In vivo CAR-T-cell HIV therapy using in vitro reconstituted virus-like particles
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11126593
This study is exploring a new way to treat HIV by changing your own T cells right in your body, so they can better find and fight HIV-infected cells, making the treatment safer and easier than older methods that involve taking your cells out for testing.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11126593 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to treating HIV by directly modifying a patient's T cells within their body, rather than extracting them for laboratory manipulation. The method involves delivering receptor genes in mRNA form to the T cells circulating in the patient's blood and lymphatic system. This innovative strategy aims to enhance the T cells' ability to recognize and attack HIV-infected cells without the risks associated with traditional extraction and transformation methods. By focusing on in vivo modifications, the research seeks to improve safety and efficacy in HIV treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have not responded adequately to existing treatments.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a safer and more effective treatment for HIV, potentially improving the quality of life for patients living with the virus.
How similar studies have performed: While the approach of in vivo T cell modification is innovative, similar immunotherapy techniques have shown promise in treating other conditions, suggesting potential for success in this area as well.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GELBART, WILLIAM M — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: GELBART, WILLIAM M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Biology of HIV Infection